Double vaccine can effectively boost immunity in polio patients
Study revolutionizes understanding of IPV.
A new study has revealed that giving combined polio vaccines can effectively boost immunity in patients. According to the study, giving the Salk inactivated poliovirus vaccine (IPV) to individuals who had already been given the Sabin live-attenuated oral poliovirus vaccine (OPV) may improve their immunity to the poliovirus, which could help resolve controversy over vaccine choice, said the study published in the journal Science.
Study's senior author Dr. Bruce Aylward, assistant director-general for Polio, Emergencies and Country Collaboration at the World Health Organization (WHO), said that the study revolutionized the understanding of IPV and how to use it in the global eradication effort to ensure children receive the best and quickest protection possible from this disease. The international research team conducted a large, community-based, randomized clinical trial in nearly 1,000 infants and children.
All subjects were given one vaccine or the other. After four weeks, all subjects, regardless of the initial dose type, got a dose of OPV. In children who were given IPV, viral shedding was reduced, meaning that these children were much less infectious to others-a key in halting the spread of the virus. The researchers also found that a single dose of IPV, which is administered by injection, induced intestinal mucosal immunity more effectively in children than an additional OPV dose.