Stem cell proteins used to regenerate bone
The stem cell-based approach was as effective as current standard treatment in terms of the amount of bone created.
Using the protein signals produced by stem cells, Scientists discovered a way to regrow bone tissue.
This technology could help treat victims who have experienced major trauma to a limb, like soldiers wounded in combat or casualties of a natural disaster, Science Daily reported.
The new method improves on older therapies by providing a sustainable source for fresh tissue and reducing the risk of tumor formation that can arise with stem cell transplants.
The new study is the first to extract the necessary bone-producing growth factors from stem cells and to show that these proteins are sufficient to create new bone.
The stem cell-based approach was as effective as the current standard treatment in terms of the amount of bone created.
"This proof-of-principle work establishes a novel bone formation therapy that exploits the regenerative potential of stem cells," says senior author Todd McDevitt, PhD, a senior investigator at the Gladstone Institutes. "With this technique, we can produce new tissue that is completely stem cell-derived and that performs similarly with the gold standard in the field."
Instead of using stem cells themselves, the scientists extracted the proteins that the cells secrete, such as bone morphogenetic protein (BMP) in order to harness their regenerative power.