Doctors in Cambodia reported the complete failure of artemisinin and piperaquine - the key drugs taken to kill malaria this year.

The discovery of resistance markers, reported in the Lancet, will allow scientists to track the threat.

Experts said the study was a big step forward.

Artemisinin resistance has been known about for years, but a recent rise in resistance to piperaquine as well means the main malaria treatment, taking both together, is starting to fail.

International groups of researchers analysed the DNA from hundreds of malaria parasites to find out how they learned to shrug off piperaquine.

They uncovered genetic signatures unique to the parasites that were drug-resistant.

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